Zoloft is a naphthylamine derivative antidepressant. It contains the substance sertraline. Zoloft selectively blocks the reuptake of serotonin by platelets and the presynaptic membrane of brain neurons. Sertraline has little effect on the reuptake of dopamine and norepinephrine. With prolonged use, it reduces the number of adrenergic receptors in the central nervous system. It has no specific affinity for adrenergic and m-cholinergic receptors, gamma-aminobutyric acid receptors, histamine, dopamine, benzodiazepine, serotonin receptors. Zoloft does not inhibit monoamine oxidase. By the end of the second week of regular intake of sertraline, an antidepressant effect is noted, and the maximum effect is achieved after 6 weeks. With the appointment of sertraline, in contrast to tricyclic antidepressants, there is no increase in body weight. Zoloft does not cause physical, mental or drug addiction. Effective for obsessive-compulsive disorders, causes anorexia.
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- treatment of depressive conditions, including those accompanied by a feeling of anxiety, in the presence and absence of mania in the anamnesis;
- prevention of initial or chronic episodes of depression (after obtaining a satisfactory clinical effect);
- treating obsessive-compulsive disorder.
Contraindications for use
Simultaneous administration of MAO inhibitors; hypersensitivity to the drug.
Side effects of Zoloft
In controlled trials with repeated doses of the drug at various doses compared with placebo, sertraline was more likely to cause the following adverse reactions: nausea, diarrhea / erratic stools, dyspepsia, tremors, dizziness, insomnia, drowsiness, sweating, dry mouth and impaired sexual function in men ( mostly delayed ejaculation). Movement disorders (such as extrapyramidal symptoms and gait disturbances), seizures, menstrual irregularities, hyperprolactinemia, galactorrhea, rash (including rare descriptions of erythema multiforme) may be present.
Rare cases of withdrawal have been reported. Possible paresthesia, hypesthesia, symptoms of depression, hallucinations, aggressive reactions, agitation, anxiety and psychosis. Rare cases of hyponatremia have been reported; after discontinuation of treatment, the sodium content returned to normal. A decrease in sodium content in most cases was observed in elderly patients, as well as in patients receiving diuretics and other drugs. If convulsions appear in all cases, the drug must be canceled.
Care must be taken when switching from other antidepressants to sertraline, especially with long-acting drugs.
With an overdose of sertraline, serotonin syndrome develops – nausea, vomiting, changes in the electrocardiogram, tachycardia, drowsiness, mydriasis, agitation, anxiety, dizziness, psychomotor agitation, increased sweating, diarrhea, hyperreflexia, myoclonus.
Treatment: taking activated carbon, it is not recommended to induce vomiting, symptomatic treatment, maintenance of vital functions.Leave a reply →